By Ailsa M. Campbell
This hugely useful ebook, and successor to quantity thirteen within the Laboratory innovations sequence, explores extra and offers extra entire, autoritative info at the construction of Mabs. a lot new and illuminating fabric has been integrated protecting the recommendations in the back of the applying of recombinant DNA know-how and biosensor expertise to monoclonal antibodies, and all of the human Mab expertise facilitated via PCR of antibody genes. additionally integrated during this most up-to-date quantity is a piece focussing on different equipment of acquiring B phone clones similar to non permanent tradition and oncogene transformation and an attractive part on Mab patents.
Read or Download Monoclonal Antibody and Immunosensor Technology: The Production and Application of Rodent and Human Monoclonal Antibodies PDF
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Additional resources for Monoclonal Antibody and Immunosensor Technology: The Production and Application of Rodent and Human Monoclonal Antibodies
Such side effects limit the dosage. In addition, mouse Mabs are frequently rejected so that a programme of continuous therapy is not practicable (reviewed by Foon, 1989). 2. Therapy of leukaemia or lymphoma Leucocyte phenotype during developmental progression is now well charted by the CD system described in Section 1 . 1 1 above. In leukaemia, there is generally a predominance of a population of abnormal lymphoid cells bearing only one or two CD antigens. Logically, it should be possible to attack such cells with a Mab directed to the leukaemia cells bearing this CD antigen.
1987). Thus the major natural response to viral infection involves a different constituency of molecules, all inaccessible to antibody. It is important to realise that by asking antibodies to tackle a viral infection without the support of the T lymphocyte arm of the immune response, the clinician is asking them to perform outwith their natural role. Viruses enter their target cells by virtue of the virus coat protein being able to attach to a normal cell surface molecule which it uses as 32 MONOCLONAL ANTlBODY AND IMMUNOSENSOR TECHNOLOGY a ‘receptor’.
6). There are two basic current strategies. The first is to make ‘genuine’ human Mabs by transforming cells with Epstein-Barr Virus (EBV) and then stabilise them by repeated cloning or backfusion (Chapters 7 and 8). , 1990) (Chapter 9). It is important to understand that the two techniques generate Mabs to different antigens and the former may be essential for some tasks (Fig. 7). Antibodies to the Rhesus antigens give the illustration. ) Rh+ individuals are tolerised to the rhesus factor and do not respond to it.