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By Claus W. Heizmann

"This very good booklet is not just prompt to these accustomed to the hot subject of calcium binding proteins yet is additionally necessary to neurobiologists, biochemists, molecular biologists and others who can observe the consequences in medical and/or pharmacological practice." magazine of normal body structure and Biophysics

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Berlin: Springer Verlag, 1991:65-103. 9. Saris C, Kristensen T, D'Eustachio P et al. eDNA sequence and tissue distribution of the mRNA for bovine and murine p 11, the S100-related light chain of the protein-tyrosine kinase substrate p36 (calpactin 1). J Biol Chern 1987; 262:10663-10671. 10. Moseley WS, Seldin MF. Definition of mouse chromosome 1 and 3 gene linkage groups that are conserved on human chromosome 1: Evidence that a conserved linkage group spans the centromere of human chromosome 1.

Membr Bio/1990; 117:101-112. Lin HC, Siidhof TC, Anderson RGW eta/. Cell/992; 70:283-291. Smythe E, Smith PO, Jacob SM eta/. I Cell Bio/1994; 124:301-306. Watanabe T, lnui M, Chen 8-Y eta/. I Bioi Chern 1994; 269:17656-17662. } Bioi Chern 1991; 266:3228-3232. Burns AL, Magendzo K, Shirvan A eta/. Proc Nat/ Acad Sci USA 1989; 86:3798-3802. Pollard HB, Rojas E. Proc Nat/ Acad Sci USA 1988; 85:2974-2978. Pollard HB, Guy HR, Arispe Net a/. Biophys} 1992; 62:19-22. Pollard HB, Rojas E, Merezhinskaya Net a/.

Major soluble proteins in the human ER include, for example, endoplasmin and calreticulin, the latter being the major Ca2 • storage protein. None of these proteins are members of the EF-hand family and, instead, coordinate Ca2 • via a duster of acidic amino acids. 80 Recently two novel resident ER proteins were identified that constitute a new subfamily of the EF-hand superfamily of Ca2 •-binding proteins. 8 1 The highest sequence identity was found to reticulocalbin, also containing six EF-hand motifs.

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